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Search Results for " Protein kinase inhibitor 6 "

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T9779	Protein kinase inhibitor 6
	Protein kinase inhibitor 6 is a protein kinase inhibitor.
T16501	PF-3644022		p38 MAPK , Serine Protease , MAPK
	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib...		p38 MAPK , Serine Protease , MAPK
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T14943	CGP60474		VEGFR , CDK , PKC
	CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently.		VEGFR , CDK , PKC
T23308	SAR407899 hydrochloride		ROCK
	ATP-competitive ROCK inhibitor		ROCK
T9095	Necrostatin-34	2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.		RIP kinase
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T2274	SC79	SC 79	Akt
	SC79 is an AKT agonist with specificity and blood-brain barrier permeability. SC79 specifically binds to the PH domain of AKT, activates cytoplasmic AKT, and inhibits AKT membrane translocation. SC79 has neuroprotective ...		Akt
T2287	PIK-75 hydrochloride	PIK-75 HCl,PIK-75	Apoptosis , DNA-PK , PI3K
	PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits DNA-PK with IC50 of 2 nM in cell-free assays.		Apoptosis , DNA-PK , PI3K
T6146	Dorsomorphin dihydrochloride	BML-275 2HCl,Compound C dihydrochloride,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride	AMPK , Autophagy , TGF-beta/Smad
	Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.		AMPK , Autophagy , TGF-beta/Smad
T60109	Protein kinase inhibitor H-7	5-(2-methylpiperazine-1-sulfonyl)isoquinoline,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine	PKC
	Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein k...		PKC
T29170	XU1	Benzo[c][1,8]naphthyridin-6(5h)-One	Aurora Kinase
	XU1（Benzo[c][1,8]naphthyridin-6(5h)-One） is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation or modulation of kinase signaling.		Aurora Kinase
T77500	Casein kinase 1δ-IN-6		Casein Kinase
	Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays.C...		Casein Kinase
T17004	TC-DAPK 6		DAPK
	TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.		DAPK
T8637	DMNB	6-Nitroveratraldehyde	DNA-PK
	DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human c...		DNA-PK
T75888	PKA Inhibitor Fragment (6-22) amide TFA	PKI-(6-22)-amide TFA,PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)	PKA
	PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of the highly potent cAMP-dependent protein kinase A (PKA) inhibitor (Ki: 2.8 nM).PKA Inhibitor Fragment (6-22) amide TFA ...		PKA
T61556	GRK6-IN-2		GRK
	GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.		GRK
T62518	GRK6-IN-1
	GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) (IC50: 120 nM). GRK6-IN-1 has the potential to be studied in multiple myeloma.
T35593	Semapimod tetrahydrochloride	CPSI-2364 tetrahydrochloride	TLR , MAPK
	Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microgl...		TLR , MAPK
TP1924L1	ZIP acetate(863987-12-6 free base)		PKC
	ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampa...		PKC
T63555	ATR-IN-6
	ATR-IN-6 is a potent inhibitor of ATR. ATR is a protein kinase that is involved in genome stability and DNA damage repair and is a member of the PIKK family. aTR-IN-6 has shown potential for ATR kinase-mediated diseases ...
T73380	CK2-IN-6
	CK2-IN-6, a powerful inhibitor of protein kinase CK2, shows promise for research in cancer, along with conditions related to kinases such as inflammation, pain, and specific immune diseases.
T63855	B-Raf IN 6
	B-Raf IN 6 is a potent inhibitor (IC50: 1.7 nM) of the protein kinase B-Raf, which does not bind the secondary target PXR and is resistant to rapid metabolism.B-Raf IN 6 has shown research potential in cancer diseases.
T76242	MMI-0100
	MMI-0100, a cell-permeant peptide inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), effectively reduces intimal hyperplasia ex vivo and in vivo. It specifically suppresses IL-6 expression w...
T79731	MLKL-IN-6		Necroptosis
	MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit...		Necroptosis
T62871	LRRK2-IN-6
	LRRK2-IN-6 (compound 22) is an orally active, selective leucine-rich repeat protein kinase 2 gene (LRRK2) inhibitor with blood-brain barrier permeability that inhibits GS LRRK2 (IC50: 4.6 μM) and WT LRRK2 (IC50: 49 μM). ...
T72289	Type II TRK inhibitor 1		Trk receptor
	Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expres...		Trk receptor
T82242	HAChE-IN-6
	hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM. It also demonstrates inhibitory effects on human butyrylcholinesterase (hBuChE) and glycogen synthase kin...
T69451	R-130823
	R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimul...
T78218	Ilaprazole sodium hydrate	IY-81149 sodium hydrate	Proton pump
	Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is employed in gastric ulcer research...		Proton pump
T38269	Purfalcamine
	Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes mala...
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM...
T83670	F1 TFA	Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide
	F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-κB kinase-interacting peptide (IKIP). It effectivel...
T23028	MRT67307 HCl (1190378-57-4 free base)	MRT67307 HCl	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i...		Others
T36684	Ipivivint
	Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM). Ipivivint reduces Wnt pathway signaling gene expression t...

Compounds

Protein kinase inhibitor 6

Target: p38 MAPK, Serine Protease, MAPK

Annaosanchun

T19659

Synonym: YC6,YC-6,YC 6

Target: VEGFR, CDK, PKC

SAR407899 hydrochloride

Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Target: RIP kinase

CCT128930 hydrochloride

T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Synonym: PIK-75 HCl,PIK-75

Target: Apoptosis, DNA-PK, PI3K

Dorsomorphin dihydrochloride

T6146

Synonym: BML-275 2HCl,Compound C dihydrochloride,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

Target: AMPK, Autophagy, TGF-beta/Smad

Protein kinase inhibitor H-7

T60109

Synonym: 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine

Target: PKC

XU1

T29170

Synonym: Benzo[c][1,8]naphthyridin-6(5h)-One

Target: Aurora Kinase

Casein kinase 1δ-IN-6

T77500

Synonym:

Target: Casein Kinase

Synonym: 6-Nitroveratraldehyde

Target: DNA-PK

PKA Inhibitor Fragment (6-22) amide TFA

T75888

Synonym: PKI-(6-22)-amide TFA,PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)

Semapimod tetrahydrochloride

T35593

Synonym: CPSI-2364 tetrahydrochloride

Target: TLR, MAPK

ZIP acetate(863987-12-6 free base)

Type II TRK inhibitor 1

Ilaprazole sodium hydrate

T78218

Synonym: IY-81149 sodium hydrate

Synonym: Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide

Target:

MRT67307 HCl (1190378-57-4 free base)

T23028

Synonym: MRT67307 HCl

カタログ番号	製品名	別名	ターゲット
T3405	[6]-Gingerol	6-Gingerol,gingerol,(S)-(+)-[6]Gingerol	Apoptosis , AMPK
	[6]-Gingerol ((S)-(+)-[6]Gingerol), an antioxidant, protects HL-60 cells from oxidative stress. It has protective effects for Yous tumors in the pancreas, ovaries, breast tissue, the bowel, among other tissues.		Apoptosis , AMPK
T13265	Urolithin B		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit...		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
TN1299	Desmethylglycitein	6,7,4'-Trihydroxyisoflavone	PI3K , CDK , PKC
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.		PI3K , CDK , PKC
T7792	Hispidin		Endogenous Metabolite , PKC
	Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties		Endogenous Metabolite , PKC
T7444	6-(Dimethylamino)purine	N,N-Dimethyladenine	Serine/threonin kinase , CDK
	6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor		Serine/threonin kinase , CDK
T6680	Staurosporine	Antibiotic AM-2282,AM-2282,CGP 41251	Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal
	Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces...
T3816	Velutin		NF-κB , HIF/HIF Prolyl-Hydroxylase
	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...		NF-κB , HIF/HIF Prolyl-Hydroxylase

天然物製品

[6]-Gingerol

T3405

Synonym: 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol

Target: Apoptosis, AMPK

Urolithin B

T13265

Synonym:

Target: ERK, NF-κB, Akt, Endogenous Metabolite, JNK, AMPK

Desmethylglycitein

TN1299

Synonym: 6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Hispidin

T7792

Synonym:

Target: Endogenous Metabolite, PKC

6-(Dimethylamino)purine

T7444

Synonym: N,N-Dimethyladenine

Target: Serine/threonin kinase, CDK

Staurosporine

T6680

Synonym: Antibiotic AM-2282,AM-2282,CGP 41251

Target: Apoptosis, PKA, Antibacterial, Antibiotic, Src, PKC, Antifungal

Velutin

T3816

Synonym:

Target: NF-κB, HIF/HIF Prolyl-Hydroxylase

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02595	DUSP14 Protein, Human, Recombinant (His & MBP)	Human	E. coli
	Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosph...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx)	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, plac...
TMPY-04542	CDK2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...
TMPJ-00827	Tau-D Protein, Human, Recombinant (His)	Human	E. coli
	Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. ...
TMPK-00614	NKp46/NCR1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expresse...
TMPY-03010	NRG1 beta 1 Protein, Human, Recombinant	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
TMPY-04277	CD45 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	CD45 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.7 kDa and the accession number is P06800-6.
TMPY-02705	NRG1 beta 1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q02297-6.
TMPY-03128	LAIR1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	LAIR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is Q8BG84-6.
TMPY-05798	VEGF145 Protein, Human, Recombinant	Human	HEK293 Cells
	VEGF145 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.92 kDa and the accession number is P15692-6.
TMPJ-00567	NCR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is...
TMPK-00615	NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expresse...
TMPY-02600	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc)	Human	HEK293 Cells
	NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is Q02297-6.
TMPK-01364	SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TMPK-01358	SIRP alpha V6 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...